I plead insanity before even asking the question. But sure, why not. Do you think Lady Gaga could make an interesting villain in Doctor Who? I was watching her vid for Bad Romance. She gives off a quirky, slightly psycho, and very alien feel. Though pretty much all of her outfits in the vid would need more cloth added, definitely.
Si-Fy and Fantasy, that is where my heart lies. To Doctor Who and its 18 years of brilliance, still waiting on the 50 yr anniversary!